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![]() ![]() ![]() But so what? There are more than enough products targeted at nerdy white guys like me, and that's probably pretty alienating if you're black and you want to lay down some dope beats - I can see how it might be preferable to work on a machine that was designed by people coming from the same musical place as you rather than what some European or Asian instrument/patch designer imagines you would want. Now, the name and the banding doesn't appeal to me because I listen to very little hip-hop and frankly as a nerdy Euro white guy I can't really relate to their music production approach. So a name like 'Beat Thang' is specifically targeted at the hip-hop market and black music-makers in general - unsurprising given the creative team behind the machine: BKE History | BKE Tech | Simpler to Sound Better ![]() I don't like the name either, but the fact is that it's no more stupid than something called the Megatron 3000 or whatever. As I said, it was a bad marketing move, and I've written before about how I think it was unwise to target the hip-hop market so specifically, which possibly limited sales and thus development revenues to get the software up to the same standards as the hardware.īut although I don't have one and don't want one, I don't care for all the sneering about it. ![]() ![]() ![]() What is the Use of MOD of Popcorn Time Apk? You cannot download any movie through this app because with the strong internet connection you can watch the movies without any limit and restriction. You can even watch as many movies you want to without any limit which is one amazing thing about it. ![]() Not only movies, you can even have a chance to read news related to different casts and celebrities so that you can have an idea about what is going on in their life. ![]() You can create your own section in the movie library. 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Let us explain the features and benefits of each type of LinkedIn account, from LinkedIn Basic (free), right up to the most expensive LinkedIn account out there, LinkedIn Recruiter. ![]() ![]() Clinical and biological characteristics of the patients referred to our institution for idarucizumab injection. ![]() To improve patient follow up after reversal and idarucizumab use in our daily practice, we analyzed the impact of initial dabigatran plasma concentrations on the incidence of rebound. We also present 10 new cases referred to our center ( Table 1). Thus, the aim of our study was to analyze clinical and biological data reported in literature to date. 6 Since we think that “no testing” before reversal is questionable, our objective was to identify a patient profile with rebound after reversal. Initial and post reversal dabigatran measurement would indeed be important for any physician deciding upon the proper use of idarucizumab. ![]() In RE-VERSE AD phase III study, the protocol did not include dabigatran measurement before administration of the antidote to guide clinical follow up plasma samples were collected before and after injection and analyzed post hoc. In REVERSE AD, these reappearances were associated with recurrent or continued bleeding in 10 patients with overt, uncontrollable, or life-threatening bleeding among which 3 required an additional dose of idarucizumab. Herein, the authors defined reappearance as an increase of the dabigatran plasma concentration above the 20ng/mL threshold of detection after reversal. However, since idarucizumab commercialization, several case studies 4 3 as well as the complete analysis of RE-VERSE AD, 5 highlighted several cases of patients either having required a second dose of idarucizumab, or with a rebound effect of plasma dabigatran levels (in 114 of 497 patients in complete RE-VERSE AD study). ![]() 2 The 5g dose was calculated to reverse the total body load of dabigatran that was associated with the 99th percentile of the dabigatran levels measured in the phase III study RE-LY. 1 Following the RE-VERSE AD trial, idarucizumab administered as a single 5g IV dose has been licensed for the management of patients with life-threatening bleeding or in case of urgent surgery/procedures while on treatment with dabigatran etexilate. ![]() Major bleeding occurs in about 4% of patients treated with direct oral anticoagulants. ![]() |
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